<scp>ER</scp> ?/ <scp>PR</scp> + breast cancer: A distinct entity, which is morphologically and molecularly close to triple?negative breast cancer
نویسندگان
چکیده
Determining the status of steroid hormone receptors [oestrogen (ER) and progesterone (PR)] is a crucial part breast cancer workup. Thereby, cancers can be classified into four subtypes. However, existence ER?/PR+ tumours, often reported to ill-classified due technical errors, remains controversial. In order address this controversy, we reviewed receptor 49 tumours previously as by immunohistochemistry, compared clinical, pathological molecular characteristics confirmed with those ER+ triple-negative tumours. We unequivocally in 27 (0.3% all diagnosed our institution between 2000 2014). found that were morphologically histologically similar but very distinct from more aggressive phenotypes frequent basal marker expression than latter. On level, RNA sequencing revealed different gene profiles three groups. Of particular interest, several genes controlled suppressor zest 12 (SUZ12) upregulated Overall, results confirm are an extremely rare ‘real’ tumour subtype requires careful diagnosis has features warranting responsiveness therapies clinical outcomes. Studies on larger cohorts needed further characterise these The likely involvement SUZ12 their biology interesting finding which may – long run give rise development new therapeutic alternatives.
منابع مشابه
Breast Cancer and Screening
سرطان پستان یکی از شایع ترین بیماریهای بدخیم و اولین علت مرگ و میر زنان بوده و تقریبا یک سوم تمام سرطانهای زنان را تشکیل می دهد.
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2021
ISSN: ['1097-0215', '0020-7136']
DOI: https://doi.org/10.1002/ijc.33539